Se comunica el caso de una paciente de 35 años con un tumor de células de Sertoli y Leydig del ovario tratado con cirugía. Además, se realiza una revisión de la literatura sobre este tipo de tumor.

Gene expression arrays and immunohistochemical phenotypes studies classified breast cancer in three distinct subtypes: basal, HER2/neu and luminal that are associated with different clinical outcomes. In 141 patients with operable breast cancer included in several phase III adjuvant therapy trials, immunohistochemical staining was performed. A basal phenotype was defined by negative estrogen and progesterone receptor and positive cytokeratin 5/6 or EGFR immunoreactivity. HER2/neu phenotype as positive c-erb B2 by HercepTest™ and luminal phenotype by positive estrogen receptors, progesterone receptors and CK 7/8 and negative HER-2 were defined respectively. Survival curves were calculated by the Kaplan-Meier method. The differences between survivals were estimated using the log rank test.

El mecanismo exacto de toxicidad ocular por tamoxifeno es desconocido; podemos decir que tiene una estructura similar a otras drogas de conocida toxicidad ocular como la imipramina, amiodarona y cloroquina. Estas drogas al poseer uniones polares y apolares con lípidos que no son metabolizados, se acumulan en los complejos intracelulares de los lisosomas.