El ejercicio físico puede representar una herramienta terapéutica entre pacientes con cáncer de mama, la aplicación de esta herramienta puede realizarse desde el mismo momento del diagnóstico, y puede mantenerse durante todo el proceso –mientras no exista ninguna situación que pueda ser contraindicada.

Los principales objetivos planteados para el ejercicio físico deben estar vinculados a la fatiga propia de la enfermedad y de los tratamientos de la misma, y, al incremento de calidad de vida gracias a una mantenimiento e incluso, incremento de las competencias motrices.

La adecuada prescripción del ejercicio físico, tanto aeróbico como PANM, no generar riesgos para el paciente, no acerba la patología y tiene efectos directos positivos sobre la fatiga y la condición física, permitiendo un mantenimiento de la independencia motriz.

Las intervenciones supervisadas en grupos afines parecen tener un mayor grado de adherencia a medio y largo plazo.

Muchos autores coinciden en ser cautos a la hora de interpretar los resultados expuestos, porque dichas evidencias están basadas en una escasa cifra de estudios, que de forma añadida poseen significativas carencias metodológicas.

Referencias bibliográficas:

1.     ACSM. The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. Med Sci Sports Exerc 1998; 30 (6):975-997.

2.     Bauman AE. Updating the evidence that PA is good for health: an epidemiological review 2000–2003. J Sci Med Sport 2004; 7: 6-19.

3.     Bicego D, Brown K Ruddick M et al. Exercise for women with or at risk for breast cancer-related lymphedema. Phys Ther 2006; 86: 1398-1405.

4.     Bicego D, Brown K, Ruddick M et al. Exercise for women with or at risk for breast cancer-related lymphedema. Phys Ther 2006; 86: 1398-1405.

5.     Brody JG, Rudel RA, Michels KB et al. Enviromental pollutants, diet, physical activity, body size and breast cancer. Cancer 2007; 109 (12 suppl): 2627-2634.

6.     Burnham TR, Wilcox A. Effects of exercise on physiological and psicological variables in cancer survivors. Med Sci Sports Exerc 2002; 34 (12):1863-1867.

7.     Cheema B, Gaul CA, Lane K & Fiatarone MA. Progressive resistance training in breast cáncer: a systematic review of clinical trials. Breast Cancer Res Treat 2008; 109 (1): 9-26.

8.     Cheema BSB, Gaul CA. Full-body exercise training improves fitness and quality of life in survivors of breast cáncer

9.     Courneya KS, Vallance JKH, McNeely ML, Karvinen KH, Peddle CJ, Mackey JR. Exercise issues in older cancer survivors. Critical reviews in oncology/ hematology 2004; 51 (3):249-261.

10.   Courneya KS. Exercise in cancer survivors: An overview of research. Med Sci Sports Exerc 2003; 35 (11):1846-1852.

11.   Courneya KS. Exercise interventions during cancer treatment: biopsychosocial outcomes. Exerc Sports Sci Rev 2001; 29 (2):60-64.

12.   Coussens LM & Werb Z. Inflammation and cancer. Nature 2002; 420 (6917):860-867.

13.   Coyle YM. Physical activity as a negative modulator of estrogen-induced breast cancer. Cancer Causes Control 2008; 19 (10): 1021-1029.

14.   Cramp F & Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev 2008; 16 (2):CD006145.

15.   Cumming SR. Primary prevention of breast cancer: new approaches. Maturitas 2007; 57 (1):39-41.

16.   De Palaville DT, Topp RV, Swank AM. Effects o aerobic training prior to and during chemotherapy in a breast cancer patient: a case study. J Strength Cond Res 2006; 21 (2) 635-637.

17.   DeNardo DG & Coussens LM. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptative and innate immune cells during breast cancer progresión. Breast Can cer Research 2007; 9:212.

18.   Febbraio MA & Pedersen BK. Contraction-induced myokine production and release: Is skeletal muscle and endocrine organ? Exerc Sport Sci Rev 2005; 33 (3):114-119.

19.   Friedenreich CM & Cust AE. Physical activity and breast cancer risk: impact of timing, type and close of dose of activity and population subgroups effects. Br J Sports Med 2008; 42 (8):636-647.

20.   Friedenreich CM & Orenstein MR. Physical activity and cancer prevention. Etiologic evidence and biological mechanisms. J Nutr 2002; 132: 3456S-3445S.

21.   Friedenreich CM. Physical activity and breast cancer risk: the effect of menopausal status. Exerc Sport Sci Rev 2004; 32 (4):180-184.

22.   Friedenreich CM. Review of anthropometric factors and breast cáncer risk. Eur J Cancer Prev 2001; 10:15-32.

23.   Galvao DA, Newton RU. Review of exercise intervention studies in cancer patients. J oh Clinical Oncology 2005; 23 (4): 899-909.

24.   Holmes MD, Chen WY, Feskanich D et al. Physical activity and survivar after breast cancer diagnosis. JAMA 2005; 293: 2479-2486.

25.   Howing JL, Broekhuizen MLA & Frings-Dresen MHW. Return to work of breast cancer survivors: a systematic review of interventions studies. BMC Cancer 2009; 9:117.

26.   Ingram C, Courneya KS & Kingston D. The effects of exercise on body weight and composition in breast cancer survivors: an integrative systematic review. Oncol Nurs Forum 2006; 33 (5):937-947.

27.   Irwin ML, McTiernan A, Bernstein L, et al. Physical activity levels among breast cancer survivors. Med Sci Sports Exerc. 2004; 36:1484-91.

28.   Irwin ML. Randomized controlled trials of physical activity and breast cancer prevention. Exerc Sports Sci Rev 2006; 34 (4):182-193.

29.   Kirshbaum MN. A review of the benefits of whole body exercise during and after treatment for breast cáncer. J Clin Nurs 2007; 16 (1): 104-121.

30.   Lee Ch D, Blair SN. Cardiorespiratory fitness and smoking-related and total cáncer mortality in men. Med Sci Sports Exerc 2002; 34 (5):735-739.

31.   Lee IM. Physical activity and cancer prevention –data from epidemiological studies. Med Sci Sports Exer 2003; 35: 1823-1827.

32.   Lucia A, Earnest C, Pérez M. Cancer-related fatigue: can exercise physiology assist oncologist? Lancet Oncol 2003; 4: 616-625.

33.   Maddocks M, Mockett S & Wilcock A. Is exercise an acceptable and practical therapy for people with or cured cancer? A systematic review. Cancer Treat Rev 2009; 35 (4):383-390.

34.   Manninkhof EM, Elias SG, Vlems FA, van der Tweel I, Schuit AJ, Voskuil DW & van Leeuwen FE. Physical activity and breast cancer: a systematic review. Epidemiology 2007; 18 (1):137-157.

35.   Marcos JF, Rubio MD. Cáncer y ejercicio. En Marcos JF y Martínez-Almagro A (ed) Envejecimiento: Problemas y soluciones. Murcia; Morphos: 2007.

36.   Markes M, Brockow T &Resch KL. Exercise for women receiving adjuvant therapy for breast cancer. Cochrane Database Syst Rev 2006; 18 (4): CD005001.

37.   McNeely ML, Campbell KL, Rowe BH, Klassen TP, Mackey JR & Courneya KS. Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis. CMAJ 2006; 175 (1):34-41.

38.   McPherson K, Steel CM & Dixon JM. Breast cancer-epidemiology, risk factors, and genetics. BMJ 2000; 321:624-628.

39.   McTiernan A, Porter P & Potter JD. Breast cancer prevention in countries with diverse resources. Cancer 2008; 113 (8 Suppl): 2325-2330.

40.   McTiernan A, Tworoger SS, Rajan KB, et al. Effect of exercise on serum androgens in postmenopausal women: A 12-month randomized clinical trial. Cancer Epidemiol Biomarkers Prev 2004; 13 (7):1099-1105.

41.   McTiernan A. Intervention studies in exercise and cancer prevention. Med Sci Sports Exerc 2003; 35 (11):1841-1845.

42.   Montazeri A. Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007. J Experimental & Clinical Cancer Research 2008; 27:32.

43.   Newton RU & Galvao DA. Exercise in prevention and management of cancer. Curr Treat Options Oncol 2008; 9 (2-3):136-146.

44.   Pérez M. Cáncer y ejercicio físico. En López J, Vaquero A (ed) Fisiología del ejercicio. Madrid: Panamerica; 2006.

45.   Petersen AMW & Pederse BK. The antiinflamatory effect of exercise. J Appl Physiol 2005; 98: 1154-1162.

46.   Pint BM & Floyd A. A methodological issues in exercise intervention research in oncology. Semin Oncol Nurs 2007; 23 (4):297-304.

47.   Pinto BM & Gloyd A. Methodological issues in exercise intervention research in oncology. Semin Oncol Nurs 2007; 23 (4):297-304.

48.   Rooney M & Wald A. Interventions for the management of weight and body composition changes in women with breast cancer. Clin J Oncol Nurs 2007; 11 (1):41-52.

49.   Schwartz AL, Mori M, Gao R, Nail LM, King ME. Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med Sci Sports Exerc 2001; 33 (5): 718-723.

50.   Smith GR & Missailidis S. Cancer, inflammation and the AT1 and AT2 receptors. J of inflammation 2004; 1:3.

51.   Sternfeld B. Cancer and the protective effect of physical activity: the epidemiological evidence. Med Sci Sports Exerc 1992; 24 (11):1195-1209.

52.   Thune I, Furberg AS. Physical activity and cancer risk: dose-response and cancer, all site and site-specific. Med Sci Sports Exerc 2001; 33 (6):S530-S550.

53.   Warburton DER, Nicol CW & Bredin SSD. Health benefits of physical activity: the evidence CMAJ 2006; 174 (&): 801-809.

54.   Westerlind KC. Physical activity and cancer prevention-mechanisms. Med Sci Sports Exerc 2003; 35 (11):1834-1840.