En el resumen, la interacción entre angiotensina II (Ang II) y desequilibrio leptina/adiponectina parecen jugar un papel importante en las alteraciones metabólicas relacionadas con la obesidad abdominal y en el riesgo de desarrollar enfermedades cardio-metabólicas en latinoamericanos.

Bibliografía.

1. Black, R.E., Allen, L.H., Bhutta, Z.A., Caulfield, L.E., De Onis, M., Ezzati, M. et al. For the maternal and child under nutrition study group. Maternal and child under nutrition: global and regional exposures and health consequences. Lancet 2008;371: 243–260.
2. Fuller, K.E. Low birth-weight infants: the continuing ethnic disparity and the interaction of biology and environment. Ethn Dis 2000; 10: 432–445.
3. López-Jaramillo, P. Defining the research priorities to fight the burden of cardiovascular diseases in Latin America. J Hypertens 2008; 26: 1886–1889.
4. Murray, C.J.L. and López, A.D. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 1997;349: 1436–1442.
5. López-Jaramillo, P., García, R. and López, M. Preventing pregnancy-induced hypertension: are there regional differences for this global problem? J Hypertens 2005; 23: 1121–1129.
6. López-Jaramillo, P. Cardio metabolic disease in Latin America: The role of fetal programming in response to maternal malnutrition. Rev Esp Cardiol 2009; 62: 670–676.
7. Gallou-Kabani, C. and Junien, C. Nutritional epigenomics of metabolic syndrome. New perspective against the epidemic. Diabetes 2005; 54: 1899–1906.
8. Aerny Perreten, N., Ramasco Gutiérrez, M., Cruz Maceín, J.L., Rodríguez Rieiro, C., Garabato González, S. and Rodríguez Laso, Á. La salud y sus determinantes en la población inmigrante de la Comunidad de Madrid. Gac Sanit 2010; 24: 136–144.
9. Gluckman, P.D., Hanson, M.A., Buklijas, T., Low, F.M. and Beedle, A.S. Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nat Rev Endocrinol 2009; 5: 401–408.
10. Bubb, K.J., Cock, M.L., Black, M.J., Dodic, M., Boon, W.M., Parkington, H.C. Intrauterine growth restriction delays cardiomyocyte maturation and alters coronary artery function in the fetal sheep. J Physiol.2007; 578: 871–881.
11. Laitinen, J., Pietilainen, K., Wadsworth, M., Sovio, U. and Jarvelin, M.R. Predictors of abdominal obesity among 31 yr old men and women born in Northern Finland in 1966. Eur J Clin Nutr 2004; 58: 180–190.
12. López-Jaramillo, P. Lahera, V. Lopez-Lopez. Epidemic of Cardiometabolic Diseases. Ther Adv Cardiovasc Dis. 2011;5(2):119-131.
13. Sing, R.S., Cullen-McEwen, L.A., Kett, M.M., Boom, W.M., Dowling, J., Bertram, J.F. Prenatal corticosterone exposure results in altered AT1/AT2, nephron deficit and hypertension in the rat offspring. J Physiol 2007; 579: 503–513.
14. Corstius, H.B., Zimanyi, M.A., Maka, N., Herath, T., Thomas, W., Vander Laarse, A.. Effect of intrauterine growth restriction on the number of cardiomyocytes in rat hearts. Pediatric Res 2005; 57: 796–800.
15. Hales, C.N. and Barker, D.J. Type 2 (noninsulin- dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992; 35: 595–601.
16. Yusuf, S., Hawken, S., Ounpuu, S., Bautista, L., Franzosi, M.G., Commerford, P. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case–control study. Lancet 2005; 366: 1640–1649.
17. Jee, S.H., Sull, J.W., Park, J., Lee, S.Y., Ohrr, H., Guallar, E. Body-mass index and mortality in Korean men and women. N Engl J Med 2006; 355: 779–787.
18. Adams, K.F., Schatzkin, A., Harris, T.B., Kipnis, V., Mouw, T., Ballard-Barbash, R. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 2006; 355: 763–778.
19. Katzmarzyk, P.T., Janssen, I., Ross, R., Church, T.S. and Balir, S.N. The importance of waist circumference in the definition of metabolic syndrome: prospective analyses of mortality in men. Diabetes Care 2006; 29: 404–409.
20. López-Jaramillo, P., Rueda-Clausen, C.F. and Silva, F.A. The utility of different definitions of metabolic syndrome in Andean population. IntJ Cardiol 2007; 116: 421–422.
21. Misra, A., Vikram, N.K., Gupta, R., Pandey, R.M., Wasir, J.S. and Gupta, V.P. Waist circumference cutoff points and action levels for Asian Indians for identification of abdominal obesity. Int Obes (Lond) 2006; 30: 106–111.
22. Velasquez-Melendez, G., Kac, G., Valente, J.G., Tavares, R., Da Silva, C.Q. and García, E.S. Evaluation of waist circumference to predict general obesity and arterial hypertension in women in Greater Metropolitan Belo Horizonte, Brazil. Cad SaudePublica 2002; 18: 765–771.
23. Berber, A., Gómez-Santos, R., Fanghanel, G. and Sanchez-Reyes, L. Anthropometric indexes in the prediction of type 2 diabetes mellitus, hypertension and dyslipidaemia in a Mexican population. Int J ObesRelat Metab Disord 2001;25: 1794–1799.
24. Pérez, M., Casas, J.P., Cubillos-Garzón, L.A., Serrano, N.C., Silva, F., Morillo, C.A. Using waist circumference as a screening tool to identify Colombian subjects at cardiovascular risk. Eur JCardiovasc Prev Rehabil 2003; 10: 328–335.
25. García, R.G., Cifuentes, A.E., Caballero, R.S., Sanchez, L. and Lopez-Jaramillo, P. A proposal for an appropriate central obesity diagnosis in Latin American population. Int J Cardiol 2006; 110: 263–264.
26. Fontana, L., Eagon, J.C., Trujillo, M.E., Scherer, P.E. and Klein, M. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007; 56: 1010–1013.
27. García, R.G., Pérez, M., Maas, R., Schwedhelm, E., Boger, R.H. and Lopez-Jaramillo, P. Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome. Int J Cardiol 2007; 122: 176–178.
28. López-Jaramillo, P. Cardio metabolic disease in Latin America: The role of fetal programming in response to maternal malnutrition. Rev Esp Cardiol 2009; 62: 670–676.
29. López-Jaramillo, P., Herrera, J.A., Arenas-Mantilla, M., Jáuregui, I.E. and Mendoza, M.A. Subclinical infection as a cause of inflammation in preeclampsia. Am J Ther 2008; 15: 373–376.
30. Lanas, F., Avezum, A., Bautista, L.E., Diaz, R., Luna, M., Islam, M. Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study. Circulation 2007; 115: 1067–1074.
31. Kabagambe, E.K., Baylin, A. and Campos, H. Nonfatal acute myocardial infarction in Costa Rica: modifiable risk factors, population-attributable risks, and adherence to dietary guidelines. Circulation 2007; 115: 1075–1081.
32. O'Donnell, M.J., Xavier, D., Liu, L., Zhang, H., Chin, S.L., Rao-Melacini, P. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case–control study. Lancet 2010;376: 112–123.
33. Rueda-Clausen, C., Silva, F. and López-Jaramillo, P. Epidemic of obesity and overweight in Latin America and the Caribbean. Int J Cardiol 2008; 125: 111–112.
34. Chandalia, M., Cabo-Chan Jr, A.V., Devaraj, S., Jialal, L., Grundy, S.M. and Abate, N. Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States. J Clin Endocrinol Metab 2003; 88: 3773–3776.
35. Harte, A., McTernan, P., Chetty, R., Coppack, S., Katz, J., Smith, S.Insulin-mediated up regulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by rosiglitazone. Circulation 2005; 111: 1954–1961.
36. Bader, M. Tissue renin–angiotensin–aldosterone systems: Targets for pharmacological therapy. Annu Rev Pharmacol Toxicol 2010; 50: 439–465.
37. Muscogiuri, G., Chavez, A.O., Gastaldelli, A., Perego, L., Tripathy, D., Saad, M.J.The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention. Curr Vasc Pharmacol 2008; 6: 301–312.
38. Kadowaki, T., Yamauchi, T., Kubota, N., Hara, K., Ueki, K. and Tobe, K. Adiponectin and adiponectin receptors in insulin resistance, diabetes and the metabolic syndrome. J Clin Invest 2006; 116: 1784–1792.
39. Shanshan, L., Shin, H.J., Ding, E.L. and Van Dam, R.M. Adiponectin levels and risk of type 2 diabetes. A systematic review and meta-analysis. JAMA 2009; 302: 179–188.
40. Rueda-Clausen, C., Lahera, V., Calderon, J., Bolivar, I.C., Castillo, V., Gutierrez, M. The presence of abdominal obesity is associated with changes in vascular function independently of other cardiovascular risk factors. Int J Cardiol 2010;139: 32–41.
41. De las Heras, N., Martín-Fernández, B., Miana, M., Ballesteros, S., Oubiña, M.P., Lopez-Farre, A.J. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance. J Hypertens Suppl 2009; 6: S37–S41.