Las hepatopatias cronicas en el contexto latinoamericano
Autor: Dr. Alfredo Arredondo Bruce | Publicado:  13/02/2012 | Medicina Preventiva y Salud Publica , Gastroenterologia , Articulos | |
Las hepatopatias cronicas en el contexto latinoamericano .3

La colangitis esclerosante primaria (CEP) es el principal diagnóstico de los pacientes hispanos en lista para trasplante hepático (1,3%). En contraste, la colangitis esclerosante primaria (CEP) es el diagnóstico más frecuente en blancos no hispanos (BNH) (5,4%) y en afroamericanos (6,4%) (50). Los datos de la UNOS indican proporciones similares en la supervivencia a los cinco años en personas hispanas que reciben un trasplante para cirrosis biliar primaria (CBP) y colangitis esclerosante primaria (CEP) (75,3 y 77,1%, respectivamente) comparado con blancos no hispanos (BNH) (78,1 y 73,6%, respectivamente). (50)

Conclusiones

La población hispana representa el crecimiento más grande y más rápido dentro de los grupos minoritarios en los Estados Unidos. A pesar de una mayor supervivencia global de hispanos contra otros grupos poblacionales, las enfermedades hepáticas son una causa importante de morbilidad y mortalidad en esta población. Los datos muestran una mayor incidencia, agresividad y peor pronóstico, inclusive después de implantado el tratamiento adecuado. Estas observaciones subrayan la importancia de reconocer las diferencias étnicas en el momento de la valoración clínica y el tratamiento a pacientes hispanos, que a menudo incluyen las barreras culturales y lingüísticas. Concluimos que la enfermedad crónica del hígado es un área de disparidad importante en la salud para las personas hispanas, necesitada de una mayor prioridad en la atención e investigación. Las áreas para la investigación futuras incluyen las características etnicoespecíficas, que podrían traducirse potencialmente en buenas estrategias para la prevención, alcanzar mejores resultados terapéuticos y, finalmente, aumentar la supervivencia en las personas hispanas con enfermedad crónica del hígado.

Referencias bibliográficas

1. US Census Bureau. Hispanic population of the United States. Disponible en:
http://www.census.gov/population/www/socdemo/hispanic/hispanic_pop_presentation.html. Último acceso Octubre 20,2011.
2. Centers for Disease Control and Prevention. CDC vital and health statistics: United States life tables by Hispanic origin. Series 2, Number 152, October 2010. Disponible en: http://www.cdc.gov/nchs/data/series/sr_02/sr02_152.pdf. Último acceso Octubre 20, 2011.
3. Morales LS, Lara M, Kington RS, et al. Socioeconomic, cultural, and behavioral factors affecting Hispanic health outcomes. J Health Care Poor Underserved 2002;13:477–503.
4. Centers for Disease Control and Prevention, CDC. Leading causes of death and numbers of deaths, by sex, race, and Hispanic origin: United States, 1980 and 2006. Disponible en:
http://www.cdc.gov/nchs/data/nvsr/nvsr58/nvsr58_14.pdf. Último acceso Octubre 20, 2011.
5. Centers for Disease Control and Prevention. National Center for Health Statistics. Health Data Interactive. Disponible en:
http://www.cdc.gov/nchs/hdi.htm. Último acceso Octubre 10, 2011.
6. Carrion A F; Ghanta R; Carrasquillo O; Martin P. Chronic Liver Disease in the Hispanic Population of the United States. Clin Gastroenterol Hepatol. 2011; 9(10):834-841.
7. Nguyen GC, Thuluvath PJ. Racial disparity in liver disease: biological, cultural, or socioeconomic factors. Hepatology 2008;47: 1058–1066.
8. Kemmer N, Neff GW. Ethnic variations in chronic liver diseases. Dig Dis Sci 2008;53:1339–1344.
9. Browning JD, Szczepaniak LS, Dobbins R. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004;40:1387–1395.
10. Yang AL, Vadhavkar S, Sing G. Epidemiology of alcohol-related liver and pancreatic disease in the United States. Arch Intern Med 2008;168:649–656.
11. Wasley A, Kruszon-Moran D, Kuhnert W. The prevalence of hepatitis B virus infection in the United States in the era of vaccination. J Infect Dis 2010;202:192–201.
12. Centers for Disease Control and Prevention (CDC). Hepatocellular carcinoma—United States, 2001–2006. MMWR Morb Mortal Wkly Rep 2010;59:517–520.
13. Mohanty SR, Troy TN, Huo D. Influence of ethnicity on histological differences in non-alcoholic fatty liver disease. J Hepatol 2009;50:797–804.
14. Williams CD, Stengel J, Asike MI. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 2011;140:124–131.
15. Schwimmer JB, McGreal N, Deutsch R. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics 2005;115:e561–e565.
16. Cheung O, Sanyal AJ. Recent advances in nonalcoholic fatty liver disease. Curr Opin Gastroenterol 2009;25:230–237.
17. Clark JM. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol 2006;40 Suppl 1:S5–S10.
18. Gholam PM, Flancbaum L, Machan JT. Nonalcoholic fatty liver disease in severely obese subjects. Am J Gastroenterol 2007;102:399–408.
19. Guerrero R, Vega GL, Grundy SM. Ethnic differences in hepatic steatosis: an insulin resistance paradox? Hepatology 2009;49:791–801.
20. Kallwitz ER, Guzman G, TenCate V. The histologic spectrum of liver disease in African-American, non-Hispanic white, and Hispanic obesity surgery patients. Am J Gastroenterol 2009;104: 64–69.
21. Romeo S, Kozlitina J, Xing C. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008;40:1461–1465.
22. Rotman Y, Koh C, Zmuda JM. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology 2010;52:894–903.
23. Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010;362:1675–1685.
24. Pekmezi DW, Neighbors CJ, Lee CS. A culturally adapted physical activity intervention for Latinas: a randomized controlled trial. Am J Prev Med 2009;37:495–500.
25. Lopez-Quintero C, Berry EM, Neumark Y. Limited English proficiency is a barrier to receipt of advice about physical activity and diet among Hispanics with chronic diseases in the United States. J Am Diet Assoc 2009;109:1769–1774.
26. Contos MJ, Cales W, Sterling RK, et al. Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis. Liver Transplant 2001; 7:363–373.
27. CDC/NCHS National Health Interview Survey, 1997–2009, Sample Adult Core component. Disponible en:
http://www.cdc.gov/nchs/data/nhis/earlyrelease/201006_09.pdf. Último acceso Noviembre 2, 2011.
28. Caetano R, Ramisetty-Mikler S, Rodriguez LA. The Hispanic Americans Baseline Alcohol Survey (HABLAS): the association between birthplace, acculturation and alcohol abuse and dependence across Hispanic national groups. Drug Alcohol Depend 2009;99:215–221.
29. Yoon YH, Yi HY, Thompson PC. Alcohol-related and viral hepatitis C-related cirrhosis mortality among Hispanic subgroups in the United States, 2000–2004. Alcohol Clin Exp Res 2011;35:240–249.
30. Field CA, Caetano R, Harris TR. Ethnic differences in drinking outcomes following a brief alcohol intervention in the trauma care setting. Addiction 2010;105:62–73.
31. Centers for Disease Control and Prevention. Surveillance for Acute Viral Hepatitis—United States, 2007. Disponible en: http://www.cdc.gov/mmwr/pdf/ss/ss5803.pdf. Último acceso: noviembre 2, 2011
32. Alter MJ, Kruszon-Moran D, Nainan OV. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med 1999;341:556–562.
33. Nainan OV, Alter MJ, Kruszon-Moran Dl. Hepatitis C virus genotypes and viral concentrations in participants of a general population survey in the United States. Gastroenterology 2006;131:478–484.
34. Trooskin SB, Navarro VJ, Winn RJ. Hepatitis C risk assessment, testing and referral for treatment in urban primary care: role of race and ethnicity. World J Gastroenterol 2007;13:1074–1078.
35. Kallwitz ER, Layden-Almer J, Dhamija M. Ethnicity and body mass index are associated with hepatitis C presentation and progression. Clin Gastroenterol Hepatol 2010;8:72–78.
36. Rodriguez-Torres M, Jeffers LJ, Sheikh MY. Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C. N Engl J Med 2009;360:257–267.
37. Yu S, Douglass JM, Qualls C. Response to therapy with pegylated interferon and ribavirin for chronic hepatitis C in Hispanics compared to non-Hispanic whites. Am J Gastroenterol 2009;104:1686–1692.
38. Mathur AK, Schaubel DE, Gong Q. Racial and ethnic disparities in access to liver transplantation. Liver Transplant 2010; 16:1033–1040.
39. Gish RG, Gadano AC. Chronic hepatitis B: current epidemiology in the Americas and implications for management. J Viral Hepat 2006;13:787–798.
40. Kim JH, Psevdos G Jr, Suh J. Co-infection of hepatitis B and hepatitis C virus in human immunodeficiency virus-infected patients in New York City, United States. World J Gastroenterol 2008;14:6689–6693.
41. Fisher DG, Reynolds GL, Jaffe A. Hepatitis and human immunodeficiency virus co-infection among injection drug users in Los Angeles County, California. J Addict Dis 2006;25:25–32.
42. Sherman KE, Anderson JW, Butt AA. Sustained long-term antiviral maintenance therapy in HCV/HIV-coinfected patients (SLAM-C). J Acquir Immune Defic Syndr 2010 Oct 1 [En prensa].
43. Perez A, Anzaldua M, McCormick J. High frequency of chronic end-stage liver disease and hepatocellular carcinoma in a Hispanic population. J Gastroenterol Hepatol 2004;19:289–295.
44. Davila JA, El-Serag HB. Racial differences in survival of hepatocellular carcinoma in the United States: a population-based study. Clin Gastroenterol Hepatol 2006;4:104–110.
45. Czaja AJ. Genetic factors affecting the occurrence, clinical phenotype, and outcome of autoimmune hepatitis. Clin Gastroenterol Hepatol 2008;6:379–388.
46. Fainboim L, Cañero Velasco MC, Marcos CY. Protracted, but not acute, hepatitis A virus infection is strongly associated with HLA-DRB*1301, a marker for pediatric autoimmune hepatitis. Hepatology 2001;33:1512–1517.
47. Bahar RJ, Yanni GS, Martín MG. Orthotopic liver transplantation for autoimmune hepatitis and cryptogenic chronic hepatitis in children. Transplantation 2001;72:829–833.
48. Peters MG, Di Bisceglie AM, Kowdley KV. Differences between Caucasian, African American, and Hispanic patients with primary biliary cirrhosis in the United States. Hepatology 2007;46:769–775.
49. Kemmer N, Neff GW. Liver transplantation in the ethnic minority population: challenges and prospects. Dig Dis Sci 2010;55:883–889.
50. Bowlus CL, Li CS, Karlsen TH, et al. Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: unique clinical and human leukocyte antigen associations. Liver Transplant 2010;16:1324–1330.


Revista Electronica de PortalesMedicos.com
INICIO - NOVEDADES - ÚLTIMO NÚMERO - ESPECIALIDADES - INFORMACIÓN AUTORES
© PortalesMedicos, S.L.
PortadaAcerca deAviso LegalPolítica de PrivacidadCookiesPublicidadContactar